I tilfelle leverproblemer eller medisinsk historie, del det med legen din og apoteket for å få den justerte dosen eller en alternativ medisin for å behandle din medisinske tilstand.
This kind of combos may possibly more lessen blood pressure level. Therefore, the usage of such mixtures is not really advised.
It can be not possible to ascertain whether these occasions are associated directly to using PDE5 inhibitors or to other components [see ADVERSE REACTIONS].
unexpected eyesight reduction in a single or both eyes. Sudden vision decline in one or both of those eyes can be a indicator of a significant eye trouble named non-arteritic anterior ischemic optic neuropathy (NAION). Quit using VIAGRA and call your healthcare supplier right away if you have sudden vision reduction in a single or both of those eyes.
This metabolite has a PDE selectivity profile just like sildenafil and an in vitro potency for PDE5 roughly fifty% in the father or mother drug. Plasma concentrations of the metabolite are about 40% of Those people witnessed for sildenafil, so which the metabolite accounts for approximately 20% of sildenafil's pharmacologic results.
Snakk med lege fileør du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet eller uregelmessige hjerteslag/hjertebank. Les pakningen og pakningsvedlegget nøye før bruk.
Physicians need to advise patients to prevent utilization of all phosphodiesterase kind five (PDE5) inhibitors, together with VIAGRA, and seek out health care interest within the event of the unexpected lack of vision in a single or both of those eyes. These an party could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a unusual problem in addition to a cause of decreased eyesight such as everlasting loss of vision, that has been noted almost never submit-marketing in temporal Affiliation with the usage of all PDE5 inhibitors.
Denne potenspillen er en behandling for menn som lider av erektil dysfunksjon (impotens) det vil si, manglende evne til å oppnå eller opprettholde en ereksjon som varer lenge nok for tilfredsstillende seksuell nytelse.
In several instances, professional medical comply with-up information was constrained. It can be impossible to ascertain no matter if these claimed occasions are associated directly to using VIAGRA, towards the affected person's underlying hazard components for hearing decline, a mix of these aspects, or to other elements [see WARNINGS AND Safety measures and Individual Facts].
It is actually removed predominantly by hepatic metabolism (largely CYP3A4) and is particularly converted to an Lively metabolite with properties similar to the mother or father, sildenafil. click here Both equally sildenafil plus the metabolite have terminal fifty percent lives of about four hours.
If you are feeling faint or dizzy, lie down. Explain to your healthcare company instantly In case you have any of the following signs or symptoms of minimal blood pressure level.
PDE3 is concerned in charge of cardiac contractility. Sildenafil is just about 10-fold as strong for PDE5 compared to PDE6, an enzyme located in the retina that is associated with the phototransduction pathway of your retina. This decreased selectivity is thought to be the basis for abnormalities associated with coloration vision [see Pharmacodynamics].
Several other medicines may well change the blood levels of sildenafil. Explain to your healthcare provider about all medicines that you take or have recently taken.
Erectile Dysfunction. For this use, sildenafil is made use of only when required. Just take it as your healthcare company suggests, which will likely be between 30 minutes to 4 several hours right before prepared sexual action. Tend not to just take double or more doses.